Rome: Total War - Alexander > Games Review

The Alexander focus seems too narrow, in my opinion, as it really only tells the final chapter of the conflict between the Greeks and Persians. ... Rome: Total War -- Alexander Review

The game starts after Philip's death and just as Alexander is poised to move against the Thebans. Once he manages to secure things in Greece, he'll be free to move against the Persians in the east. To win the campaign game, you'll have to capture thirty territories. Though you'll have to hold a few specific territories, capturing thirty territories is basically the same as capturing the whole map so you really won't have to worry too much about getting the right territories.

You will however have to worry about achieving your goals within the 100-turn time limit. (Since Alexander's conquests lasted only 13 years, the game dispenses with the year-by-year system and just progresses turn-by-turn.)